Amlodipino [Spanish]
Brand names,
Amlodipino [Spanish]
Analogs
Amlodipino [Spanish]
Brand Names Mixture
- Lotrel (amlodipine + benazepril)
Amlodipino [Spanish]
Chemical_Formula
C20H25ClN2O5
Amlodipino [Spanish]
RX_link
http://www.rxlist.com/cgi/generic/amlod2.htm
Amlodipino [Spanish]
fda sheet
Amlodipino [Spanish]
msds (material safety sheet)
Amlodipino [Spanish]
Synthesis Reference
S. F. Campbell et al., U.S. Pat. 4,572,909 (1986)
Amlodipino [Spanish]
Molecular Weight
408.876 g/mol
Amlodipino [Spanish]
Melting Point
178-179oC
Amlodipino [Spanish]
H2O Solubility
75.3 mg/L
Amlodipino [Spanish]
State
Solid
Amlodipino [Spanish]
LogP
2.347
Amlodipino [Spanish]
Dosage Forms
Tablets (equivalent to 2.5, 5 and 10 mg)
Amlodipino [Spanish]
Indication
For the treatment of hypertension, chronic stable angina and confirmed or suspected vasospastic angina.
Amlodipino [Spanish]
Pharmacology
Amlodipine, a calcium-channel blocker, is used alone or with benazepril, an angiotensin-converting enzyme inhibitor, to treat hypertension, chronic stable angina pectoris, and Prinzmetal's variant angina. Amlodipine is similar to the peripheral vasodilator nifedipine and other members of the dihydropyridine class.
Amlodipino [Spanish]
Absorption
Amlodipine is slowly and almost completely absorbed from the gastrointestinal tract.
Amlodipino [Spanish]
side effects and Toxicity
Gross overdosage could result in excessive peripheral vasodilatation and possibly reflex tachycardia. Marked and probably prolonged systemic hypotension up to an including shock with fatal outcome have been reported.
Amlodipino [Spanish]
Patient Information
Amlodipino [Spanish]
Organisms Affected
Humans and other mammals